Semaglutide is a peptide medication commonly used for weight loss by mimicking the effects of GLP-1 (glucagon-like peptide-1), a hormone naturally produced in the intestines in response to eating. This hormone plays a key role in weight regulation through several mechanisms:

• Appetite Suppression: Semaglutide acts on the brain's appetite control centers, reducing hunger and increasing the feeling of fullness, which decreases the desire for food.
• Slowed Gastric Emptying: It slows down the emptying of the stomach, extending the feeling of fullness after meals, which helps reduce overall food intake.
• Blood Sugar Regulation: By stimulating insulin release only when necessary, semaglutide helps maintain stable blood sugar levels, preventing overeating caused by blood sugar fluctuations.
• Lower Caloric Intake: By curbing hunger and food cravings, semaglutide helps individuals consume fewer calories, which is crucial for weight loss.
• Enhanced Energy Expenditure: Semaglutide may also boost energy expenditure, contributing to additional weight loss.

Typically, semaglutide is part of a comprehensive weight management plan that includes a reduced-calorie diet and increased physical activity. It’s not a stand-alone treatment and should be prescribed and monitored by a healthcare professional to ensure safe and effective use.

Yes, semaglutide is FDA-approved for weight loss. In 2021, it received FDA approval as a weight loss medication, marking a significant advancement in the search for effective weight management solutions. Semaglutide is designed to assist in chronic weight management and can help individuals achieve considerable weight loss when used alongside a balanced diet and exercise program. Losing 5% to 10% of body weight through these lifestyle changes has been linked to improved health outcomes.

Along with its needed effects, semaglutide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking semaglutide:

More common side effects

• anxiety
• bloating
• blurred vision
• chills
• cold sweats
• confusion
• constipation
• cool, pale skin
• cough
• darkened urine
• depression
• diarrhea
• difficulty swallowing
• dizziness
• fast heartbeat
• fever
• headache
• increased hunger
• indigestion
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of appetite
• nausea
• nervousness
• nightmare
• pain in the stomach, side, or abdomen, possibly radiating to the back
• seizures
• skin rash
• slurred speech
• tightness in the chest
• trouble breathing
• unusual tiredness or weakness
• vomiting
• yellow eyes or skin

Other side effects of semaglutide

Some side effects of semaglutide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• acid or sour stomach
• belching
• excess air or gas in stomach
• feeling pressure in the stomach
• heartburn
• passing gas
• stomach discomfort, swelling, tenderness, or upset

To identify suitable candidates for semaglutide, several important factors should be evaluated:

• BMI Criteria: Individuals with a body mass index (BMI) of 30 or higher may qualify for semaglutide. Those with a BMI of 27 may also be eligible if they have one or more weight-related health conditions, such as type 2 diabetes, high blood pressure, or high cholesterol.
• Weight Loss Goals: Semaglutide is typically prescribed for individuals struggling with obesity who have not achieved significant weight loss through diet and exercise alone.
• Comfort with Injections: Since semaglutide is administered via self-injections, individuals who are comfortable with this method may be well-suited for the treatment.
• Consultation with a Healthcare Provider: The decision to use semaglutide should always involve a consultation with a healthcare provider, who can evaluate an individual’s health status, weight loss objectives, and overall suitability for the medication.

Semaglutide is a medication designed primarily for two key purposes: managing type 2 diabetes and facilitating long-term weight management in individuals with obesity. It is marketed under various brand names, including Ozempic, Wegovy, and Rybelsus. Semaglutide is renowned for its effectiveness in controlling blood sugar levels for diabetes patients and promoting significant weight loss in those struggling with obesity.

As a member of the glucagon-like peptide-1 (GLP-1) receptor agonist class, semaglutide mimics the actions of the body's natural GLP-1 hormones. This mechanism leads to increased insulin secretion, decreased glucagon production, slowed gastric emptying, and reduced appetite. Together, these effects not only help regulate blood sugar levels but also support weight reduction in individuals with obesity.

Semaglutide has demonstrated encouraging outcomes for weight loss in both clinical trials and real-world studies. After 68 weeks of treatment, half of the participants using semaglutide lost 15% of their body weight, while nearly one-third experienced a loss of 20%.

On average, the expected weight loss with semaglutide can differ based on factors such as dosage, individual response, and duration of use. Here are some key insights:

• Clinical Studies: Research involving semaglutide has demonstrated significant weight loss results. Patients taking a dose of 2.4 mg lost an average of 6% of their body weight by week 12 and 12% by week 28.
• Individual Variability: It's essential to recognize that individual responses to semaglutide can vary. While some may experience more considerable weight loss, others might achieve more modest results.
• Dosage Matters: The dosage of semaglutide can influence the amount of weight lost. Higher doses may result in more significant weight loss; however, they should only be prescribed and monitored by a healthcare professional.

Semaglutide has demonstrated encouraging results in supporting weight loss. The specific amount of weight loss experienced while taking semaglutide can differ among individuals, influenced by factors such as diet, exercise, and personal response to the medication.

Semaglutide is not a fast solution for weight loss. It usually takes several weeks to months of treatment to achieve weight loss goals. It is prescribed for individuals dealing with obesity as part of a complete weight management plan that includes lifestyle changes such as a healthy diet and regular exercise.

Many individuals begin to see weight loss within the first few weeks of starting semaglutide. The amount of weight lost in the initial week can vary based on factors such as diet, exercise, and individual metabolism. More significant weight loss may require additional time.

The effectiveness of semaglutide for weight loss can be affected by lifestyle choices, adherence to the treatment plan, and personal differences. For personalized advice on using semaglutide for weight loss, consult with a healthcare professional who can offer tailored recommendations and monitor your progress.

Semaglutide significantly impacts hunger and appetite control. Research shows that it helps reduce hunger, food cravings, and improves overall control of eating habits. Additionally, semaglutide often lowers the preference for high-fat foods, contributing to weight loss. Unlike natural GLP-1, which is quickly broken down by enzymes in the body and can lead to increased hunger, semaglutide is designed to be more stable and longer-lasting. This extended action helps suppress appetite and reduce hunger, especially after meals, supporting more effective weight management.

Typically, the dosage of semaglutide is increased gradually. For adults, the usual starting dose is 0.25 mg once a week for the first four weeks. After this initial period, the dose is increased to 0.5 mg once a week. If necessary and with a doctor’s supervision, the dose may be further increased to 1.0 mg once a week for additional weight loss, with a maximum dose of up to 2.4 mg.

Semaglutide should be used only under the guidance of a healthcare provider. A doctor will determine the appropriate dosage and treatment plan based on individual health conditions and weight loss objectives.

Semaglutide injection is given once a week and can be administered at any time of the day, regardless of meals. It is advisable to maintain consistency with the same day and time each week. Be sure to follow the dosage and schedule recommended by your healthcare provider.

Semaglutide is administered through a subcutaneous injection, meaning it is injected just beneath the skin. Common injection sites include the abdomen, thigh, or arm. The choice of injection site may vary based on individual preferences and recommendations from healthcare providers. To avoid irritation or lumps under the skin, it’s essential to rotate injection sites regularly.

When using semaglutide, it’s generally recommended to limit or avoid alcohol. While alcohol doesn’t directly interact with semaglutide, it can raise the likelihood of experiencing unwanted side effects, such as digestive issues or blood sugar fluctuations. Reducing alcohol intake can help ensure the treatment works more effectively and safely.

Semaglutide can be used long-term for managing type 2 diabetes, while in weight management, it is typically used short-term until the desired weight loss is achieved.

The duration of semaglutide treatment for weight loss can vary, but it is usually recommended for a specific period. Typically, semaglutide is prescribed for 12 weeks as part of a weight loss program. During this time, patients receive regular semaglutide injections while adhering to a comprehensive weight management plan that includes dietary modifications and increased physical activity. The exact duration will be determined by your healthcare provider based on your individual needs and progress.

Semaglutide is not intended as a lifelong weight loss treatment. After the initial treatment period, your healthcare provider will evaluate your progress to decide if further treatment is needed or if you can shift to other maintenance strategies to maintain your weight loss.

The time required to notice results with semaglutide for weight loss can differ among individuals.

• Initial Changes: Some people may start to observe initial weight changes within a few weeks of beginning semaglutide treatment.
• Significant Progress: Achieving more substantial weight loss typically requires several weeks to months of treatment. The rate of weight loss can be influenced by various factors, including the individual’s starting weight, diet, exercise habits, and overall lifestyle.
• Patience and Consistency: Reaching and maintaining a healthy weight is a gradual process, so patience is essential. Patients should adhere to their healthcare provider’s guidance and maintain consistent treatment to optimize the benefits of semaglutide for weight loss.
• Individual Variations: It’s important to remember that responses to semaglutide can vary among individuals. Some may see quicker results, while others might take longer to achieve significant changes.

Once you reach your weight loss goals with semaglutide, discontinuing the medication may result in weight regain. To reduce the risk of regaining weight, it’s important to establish a maintenance plan. This plan should include maintaining healthy eating habits and engaging in regular physical activity to help sustain your weight loss.

To effectively manage weight with semaglutide, it is essential to implement lifestyle changes, such as maintaining a healthy diet and engaging in regular exercise.

When using semaglutide for weight loss, following these dietary and lifestyle recommendations can enhance its effectiveness and ensure your safety:

• Healthy Eating: Prioritize a balanced and nutritious diet rich in fruits, vegetables, lean proteins, whole grains, and healthy fats. This approach helps regulate calorie intake while promoting overall health.
• Portion Control: Pay attention to portion sizes to prevent overeating. While semaglutide may help suppress appetite, maintaining portion control is crucial for achieving success.
• Foods to Avoid: Limit or eliminate high-calorie, high-sugar, and high-fat foods, along with processed snacks and sugary drinks, as these can undermine the effects of semaglutide.
• Regular Exercise: Include physical activity in your daily routine. Regular exercise can accelerate weight loss and enhance overall well-being.
• Hydration: Stay adequately hydrated by drinking enough water each day. Proper hydration can help manage hunger and support your weight loss efforts.
• Medical Supervision: Always use semaglutide under the supervision of a healthcare professional. They can monitor your progress, adjust your dosage as necessary, and offer personalized guidance.

Some benefits of semaglutide include:

• Effective Weight Loss: Semaglutide has demonstrated significant weight loss results when combined with a healthy diet and regular exercise, making it an attractive option for those dealing with obesity.
• Reduced Cardiometabolic Risk: Clinical studies suggest that weight loss achieved through semaglutide is linked to meaningful improvements in various cardiometabolic risk factors, thereby decreasing the likelihood of heart disease and stroke in overweight or obese individuals.
• Lower Risk of Diabetes: When paired with lifestyle modifications, semaglutide may help lower the risk of developing diabetes.

Some risks associated with semaglutide include:

• Potential Side Effects: As with any medication, semaglutide can cause side effects, which may include nausea, vomiting, and diarrhea.
• Cost: Semaglutide may not be covered by insurance, making it potentially unaffordable for some individuals.

Semaglutide may interact with medications that lower blood sugar levels, including insulin, sulfonylureas, and meglitinides. Additionally, it could affect the absorption of oral medications and interact with other drugs or treatments. It’s important to adhere to the guidance provided by your healthcare professionals when managing these interactions.

At this time, our semaglutide weight loss program is self-pay only, and we do not accept insurance for semaglutide treatments. The cost of the program includes weekly injections and ongoing support, but you’ll need to cover the fees independently.

As a medication, you can bring semaglutide through airport security, but be prepared for security personnel to ask to scan it separately. Since the pens contain liquid, they may need to be placed in a plastic bag. It's important to keep your syringes and needles in their original packaging with the prescription label intact. Depending on the specific medication you have and whether it has been opened, semaglutide may require refrigeration, so you might need to pack it with ice. Be sure to follow the storage guidelines provided with your medication. It's also advisable to carry a doctor's prescription or a note explaining the necessity of the medication.

Typically, semaglutide should be refrigerated at a temperature between 36°F and 46°F (2°C and 8°C) prior to its initial use. Once the pen is in use, it can be stored in a cool place without needing to remain in the refrigerator. It’s important to avoid exposing it to extreme temperatures and to always follow the specific storage instructions provided by the manufacturer.